Phase III randomised controlled trial of neoadjuvant chemotherapy plus radical surgery vs radical surgery alone for stages IB2, IIA2, and IIB cervical cancer: a Japan Clinical Oncology Group trial (JCOG 0102)
Identifieur interne : 003301 ( Main/Exploration ); précédent : 003300; suivant : 003302Phase III randomised controlled trial of neoadjuvant chemotherapy plus radical surgery vs radical surgery alone for stages IB2, IIA2, and IIB cervical cancer: a Japan Clinical Oncology Group trial (JCOG 0102)
Auteurs : N. Katsumata [Japon] ; H. Yoshikawa [Japon] ; H. Kobayashi [Japon] ; T. Saito [Japon] ; K. Kuzuya [Japon] ; T. Nakanishi [Japon] ; T. Yasugi [Japon] ; N. Yaegashi [Japon] ; H. Yokota [Japon] ; S. Kodama [Japon] ; T. Mizunoe [Japon] ; M. Hiura [Japon] ; T. Kasamatsu [Japon] ; T. Shibata [Japon] ; T. Kamura [Japon]Source :
- British Journal of Cancer [ 0007-0920 ] ; 2013.
Abstract
A phase III trial was conducted to determine whether neoadjuvant chemotherapy (NACT) before radical surgery (RS) improves overall survival.
Patients with stage IB2, IIA2, or IIB squamous cell carcinoma of the uterine cervix were randomly assigned to receive either BOMP (bleomycin 7 mg days 1–5, vincristine 0.7 mg m−2 day 5, mitomycin 7 mg m−2 day 5, cisplatin 14 mg m−2 days 1–5, every 3 weeks for 2 to 4 cycles) plus RS (NACT group) or RS alone (RS group). Patients with pathological high-risk factors received postoperative radiotherapy (RT). The primary end point was overall survival.
A total of 134 patients were randomly assigned to treatment. This study was prematurely terminated at the first planned interim analysis because overall survival in the NACT group was inferior to that in the RS group. Patients who received postoperative RT were significantly lower in the NACT group (58%) than in the RS group (80%
Neoadjuvant chemotherapy with BOMP regimen before RS did not improve overall survival, but reduced the number of patients who received postoperative RT.
Url:
DOI: 10.1038/bjc.2013.179
PubMed: 23640393
PubMed Central: 3671094
Affiliations:
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Yaegashi</name><affiliation wicri:level="1"><nlm:aff id="aff8"><institution>Department of Obstetrics and Gynecology, Tohoku University</institution>, Sendai,<country>Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Yokota, H" sort="Yokota, H" uniqKey="Yokota H" first="H" last="Yokota">H. Yokota</name><affiliation wicri:level="1"><nlm:aff id="aff9"><institution>Department of Gynecologic Oncology, Saitama Cancer Center</institution>, Saitama,<country>Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kodama, S" sort="Kodama, S" uniqKey="Kodama S" first="S" last="Kodama">S. Kodama</name><affiliation wicri:level="1"><nlm:aff id="aff10"><institution>Department of Gynecologic Oncology, Niigata Cancer Center</institution>, Niigata,<country>Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mizunoe, T" sort="Mizunoe, T" uniqKey="Mizunoe T" first="T" last="Mizunoe">T. Mizunoe</name><affiliation wicri:level="1"><nlm:aff id="aff11"><institution>Department of Gynecologic Oncology, Kure Medical Center</institution>, Kure,<country>Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hiura, M" sort="Hiura, M" uniqKey="Hiura M" first="M" last="Hiura">M. Hiura</name><affiliation wicri:level="1"><nlm:aff id="aff12"><institution>Department of Gynecologic Oncology, Shikoku Cancer Center</institution>, Matsuyama,<country>Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kasamatsu, T" sort="Kasamatsu, T" uniqKey="Kasamatsu T" first="T" last="Kasamatsu">T. Kasamatsu</name><affiliation wicri:level="1"><nlm:aff id="aff13"><institution>Department of Gynecologic Oncology, National Cancer Center Hospital</institution>, Tokyo,<country>Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Shibata, T" sort="Shibata, T" uniqKey="Shibata T" first="T" last="Shibata">T. Shibata</name><affiliation wicri:level="1"><nlm:aff id="aff14"><institution>Japan Clinical Oncology Group Data Center, Multi-institutional Clinical Trial Support Center, National Cancer Center</institution>, Tokyo,<country>Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kamura, T" sort="Kamura, T" uniqKey="Kamura T" first="T" last="Kamura">T. Kamura</name><affiliation wicri:level="1"><nlm:aff id="aff15"><institution>Department of Obstetrics and Gynecology, Kurume University</institution>, Kurume,<country>Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">23640393</idno><idno type="pmc">3671094</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3671094</idno><idno type="RBID">PMC:3671094</idno><idno type="doi">10.1038/bjc.2013.179</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">000076</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000076</idno><idno type="wicri:Area/Pmc/Curation">000076</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000076</idno><idno type="wicri:Area/Pmc/Checkpoint">002073</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">002073</idno><idno type="wicri:Area/Ncbi/Merge">005881</idno><idno type="wicri:Area/Ncbi/Curation">005881</idno><idno type="wicri:Area/Ncbi/Checkpoint">005881</idno><idno type="wicri:doubleKey">0007-0920:2013:Katsumata N:phase:iii:randomised</idno><idno type="wicri:Area/Main/Merge">003307</idno><idno type="wicri:Area/Main/Curation">003301</idno><idno type="wicri:Area/Main/Exploration">003301</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Phase III randomised controlled trial of neoadjuvant chemotherapy plus radical surgery <italic>vs</italic> radical surgery alone for stages IB2, IIA2, and IIB cervical cancer: a Japan Clinical Oncology Group trial (JCOG 0102)</title><author><name sortKey="Katsumata, N" sort="Katsumata, N" uniqKey="Katsumata N" first="N" last="Katsumata">N. Katsumata</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Medical Oncology, Nippon Medical School Musashikosugi Hospital</institution>, Kawasaki,<country>Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Yoshikawa, H" sort="Yoshikawa, H" uniqKey="Yoshikawa H" first="H" last="Yoshikawa">H. Yoshikawa</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Department of Obstetrics and Gynecology, University of Tsukuba</institution>, Tsukuba,<country>Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kobayashi, H" sort="Kobayashi, H" uniqKey="Kobayashi H" first="H" last="Kobayashi">H. Kobayashi</name><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Department of Obstetrics and Gynecology, Kyushu University</institution>, Fukuoka,<country>Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Saito, T" sort="Saito, T" uniqKey="Saito T" first="T" last="Saito">T. Saito</name><affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Department of Gynecologic Oncology, Kyushu Cancer Center</institution>, Fukuoka,<country>Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kuzuya, K" sort="Kuzuya, K" uniqKey="Kuzuya K" first="K" last="Kuzuya">K. Kuzuya</name><affiliation wicri:level="1"><nlm:aff id="aff5"><institution>Kuzuya Clinic</institution>, Nagoya,<country>Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Nakanishi, T" sort="Nakanishi, T" uniqKey="Nakanishi T" first="T" last="Nakanishi">T. Nakanishi</name><affiliation wicri:level="1"><nlm:aff id="aff6"><institution>Department of Gynecologic Oncology, Aichi Cancer Center</institution>, Nagoya,<country>Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Yasugi, T" sort="Yasugi, T" uniqKey="Yasugi T" first="T" last="Yasugi">T. Yasugi</name><affiliation wicri:level="1"><nlm:aff id="aff7"><institution>Department of Obstetrics and Gynecology, Tokyo University</institution>, Tokyo,<country>Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Yaegashi, N" sort="Yaegashi, N" uniqKey="Yaegashi N" first="N" last="Yaegashi">N. Yaegashi</name><affiliation wicri:level="1"><nlm:aff id="aff8"><institution>Department of Obstetrics and Gynecology, Tohoku University</institution>, Sendai,<country>Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Yokota, H" sort="Yokota, H" uniqKey="Yokota H" first="H" last="Yokota">H. Yokota</name><affiliation wicri:level="1"><nlm:aff id="aff9"><institution>Department of Gynecologic Oncology, Saitama Cancer Center</institution>, Saitama,<country>Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kodama, S" sort="Kodama, S" uniqKey="Kodama S" first="S" last="Kodama">S. Kodama</name><affiliation wicri:level="1"><nlm:aff id="aff10"><institution>Department of Gynecologic Oncology, Niigata Cancer Center</institution>, Niigata,<country>Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mizunoe, T" sort="Mizunoe, T" uniqKey="Mizunoe T" first="T" last="Mizunoe">T. Mizunoe</name><affiliation wicri:level="1"><nlm:aff id="aff11"><institution>Department of Gynecologic Oncology, Kure Medical Center</institution>, Kure,<country>Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hiura, M" sort="Hiura, M" uniqKey="Hiura M" first="M" last="Hiura">M. Hiura</name><affiliation wicri:level="1"><nlm:aff id="aff12"><institution>Department of Gynecologic Oncology, Shikoku Cancer Center</institution>, Matsuyama,<country>Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kasamatsu, T" sort="Kasamatsu, T" uniqKey="Kasamatsu T" first="T" last="Kasamatsu">T. Kasamatsu</name><affiliation wicri:level="1"><nlm:aff id="aff13"><institution>Department of Gynecologic Oncology, National Cancer Center Hospital</institution>, Tokyo,<country>Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Shibata, T" sort="Shibata, T" uniqKey="Shibata T" first="T" last="Shibata">T. Shibata</name><affiliation wicri:level="1"><nlm:aff id="aff14"><institution>Japan Clinical Oncology Group Data Center, Multi-institutional Clinical Trial Support Center, National Cancer Center</institution>, Tokyo,<country>Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kamura, T" sort="Kamura, T" uniqKey="Kamura T" first="T" last="Kamura">T. Kamura</name><affiliation wicri:level="1"><nlm:aff id="aff15"><institution>Department of Obstetrics and Gynecology, Kurume University</institution>, Kurume,<country>Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">British Journal of Cancer</title><idno type="ISSN">0007-0920</idno><idno type="eISSN">1532-1827</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background:</title><p>A phase III trial was conducted to determine whether neoadjuvant chemotherapy (NACT) before radical surgery (RS) improves overall survival.</p></sec><sec><title>Methods:</title><p>Patients with stage IB2, IIA2, or IIB squamous cell carcinoma of the uterine cervix were randomly assigned to receive either BOMP (bleomycin 7 mg days 1–5, vincristine 0.7 mg m<sup>−2</sup> day 5, mitomycin 7 mg m<sup>−2</sup> day 5, cisplatin 14 mg m<sup>−2</sup> days 1–5, every 3 weeks for 2 to 4 cycles) plus RS (NACT group) or RS alone (RS group). Patients with pathological high-risk factors received postoperative radiotherapy (RT). The primary end point was overall survival.</p></sec><sec><title>Results:</title><p>A total of 134 patients were randomly assigned to treatment. This study was prematurely terminated at the first planned interim analysis because overall survival in the NACT group was inferior to that in the RS group. Patients who received postoperative RT were significantly lower in the NACT group (58%) than in the RS group (80% <italic>P</italic>=0.015). The 5-year overall survival was 70.0% in the NACT group and 74.4% in the RS group (<italic>P</italic>=0.85).</p></sec><sec><title>Conclusion:</title><p>Neoadjuvant chemotherapy with BOMP regimen before RS did not improve overall survival, but reduced the number of patients who received postoperative RT.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Buda, A" uniqKey="Buda A">A Buda</name></author><author><name sortKey="Fossati, R" uniqKey="Fossati R">R Fossati</name></author><author><name sortKey="Colombo, N" uniqKey="Colombo N">N Colombo</name></author><author><name sortKey="Fei, F" uniqKey="Fei F">F Fei</name></author><author><name sortKey="Floriani, I" uniqKey="Floriani I">I Floriani</name></author><author><name sortKey="Gueli Alletti, D" uniqKey="Gueli Alletti D">D Gueli Alletti</name></author><author><name sortKey="Katsaros, D" uniqKey="Katsaros D">D Katsaros</name></author><author><name sortKey="Landoni, F" uniqKey="Landoni F">F Landoni</name></author><author><name sortKey="Lissoni, A" uniqKey="Lissoni A">A Lissoni</name></author><author><name sortKey="Malzoni, C" uniqKey="Malzoni C">C Malzoni</name></author><author><name sortKey="Sartori, E" uniqKey="Sartori E">E Sartori</name></author><author><name sortKey="Scollo, P" uniqKey="Scollo P">P Scollo</name></author><author><name sortKey="Torri, V" uniqKey="Torri V">V Torri</name></author><author><name sortKey="Zola, P" uniqKey="Zola P">P Zola</name></author><author><name sortKey="Mangioni, C" uniqKey="Mangioni C">C Mangioni</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cai, Hb" uniqKey="Cai H">HB Cai</name></author><author><name sortKey="Chen, Hz" uniqKey="Chen H">HZ Chen</name></author><author><name sortKey="Yin, Hh" uniqKey="Yin H">HH Yin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, H" uniqKey="Chen H">H Chen</name></author><author><name sortKey="Liang, C" uniqKey="Liang C">C Liang</name></author><author><name sortKey="Zhang, L" uniqKey="Zhang L">L Zhang</name></author><author><name sortKey="Huang, S" uniqKey="Huang S">S Huang</name></author><author><name sortKey="Wu, X" uniqKey="Wu X">X Wu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Eddy, Gl" uniqKey="Eddy G">GL Eddy</name></author><author><name sortKey="Bundy, Bn" uniqKey="Bundy B">BN Bundy</name></author><author><name sortKey="Creasman, Wt" uniqKey="Creasman W">WT Creasman</name></author><author><name sortKey="Spirtos, Nm" uniqKey="Spirtos N">NM Spirtos</name></author><author><name sortKey="Mannel, Rs" uniqKey="Mannel R">RS Mannel</name></author><author><name sortKey="Hannigan, E" uniqKey="Hannigan E">E Hannigan</name></author><author><name sortKey="O Connor, D" uniqKey="O Connor D">D O'Connor</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Fujii, S" uniqKey="Fujii S">S Fujii</name></author><author><name sortKey="Takakura, K" uniqKey="Takakura K">K Takakura</name></author><author><name sortKey="Matsumura, N" uniqKey="Matsumura N">N Matsumura</name></author><author><name sortKey="Higuchi, T" uniqKey="Higuchi T">T Higuchi</name></author><author><name sortKey="Yura, S" uniqKey="Yura S">S Yura</name></author><author><name sortKey="Mandai, M" uniqKey="Mandai M">M Mandai</name></author><author><name sortKey="Baba, T" uniqKey="Baba T">T Baba</name></author><author><name sortKey="Yoshioka, S" uniqKey="Yoshioka S">S Yoshioka</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Green, S" uniqKey="Green S">S Green</name></author><author><name sortKey="Benedetti, J" uniqKey="Benedetti J">J Benedetti</name></author><author><name sortKey="Crowley, J" uniqKey="Crowley J">J Crowley</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Katsumata, N" uniqKey="Katsumata N">N Katsumata</name></author><author><name sortKey="Yoshikawa, H" uniqKey="Yoshikawa H">H Yoshikawa</name></author><author><name sortKey="Hirakawa, T" uniqKey="Hirakawa T">T Hirakawa</name></author><author><name sortKey="Saito, T" uniqKey="Saito T">T Saito</name></author><author><name sortKey="Kuzuya, K" uniqKey="Kuzuya K">K Kuzuya</name></author><author><name sortKey="Fujii, T" uniqKey="Fujii T">T Fujii</name></author><author><name sortKey="Hiura, M" uniqKey="Hiura M">M Hiura</name></author><author><name sortKey="Tsunematsu, R" uniqKey="Tsunematsu R">R Tsunematsu</name></author><author><name sortKey="Fukuda, H" uniqKey="Fukuda H">H Fukuda</name></author><author><name sortKey="Kamura, T" uniqKey="Kamura T">T Kamura</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Long, Hj" uniqKey="Long H">HJ Long</name></author><author><name sortKey="Bundy, Bn" uniqKey="Bundy B">BN Bundy</name></author><author><name sortKey="Grendys, Ec" uniqKey="Grendys E">EC Grendys</name></author><author><name sortKey="Benda, Ja" uniqKey="Benda J">JA Benda</name></author><author><name sortKey="Mcmeekin, Ds" uniqKey="Mcmeekin D">DS McMeekin</name></author><author><name sortKey="Sorosky, J" uniqKey="Sorosky J">J Sorosky</name></author><author><name sortKey="Miller, Ds" uniqKey="Miller D">DS Miller</name></author><author><name sortKey="Eaton, La" uniqKey="Eaton L">LA Eaton</name></author><author><name sortKey="Fiorica, Jv" uniqKey="Fiorica J">JV Fiorica</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Matsumura, M" uniqKey="Matsumura M">M Matsumura</name></author><author><name sortKey="Takeshima, N" uniqKey="Takeshima N">N Takeshima</name></author><author><name sortKey="Ota, T" uniqKey="Ota T">T Ota</name></author><author><name sortKey="Omatsu, K" uniqKey="Omatsu K">K Omatsu</name></author><author><name sortKey="Sakamoto, K" uniqKey="Sakamoto K">K Sakamoto</name></author><author><name sortKey="Kawamata, Y" uniqKey="Kawamata Y">Y Kawamata</name></author><author><name sortKey="Umayahara, K" uniqKey="Umayahara K">K Umayahara</name></author><author><name sortKey="Tanaka, H" uniqKey="Tanaka H">H Tanaka</name></author><author><name sortKey="Akiyama, F" uniqKey="Akiyama F">F Akiyama</name></author><author><name sortKey="Takizawa, K" uniqKey="Takizawa K">K Takizawa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Moore, Dh" uniqKey="Moore D">DH Moore</name></author><author><name sortKey="Blessing, Ja" uniqKey="Blessing J">JA Blessing</name></author><author><name sortKey="Mcquellon, Rp" uniqKey="Mcquellon R">RP McQuellon</name></author><author><name sortKey="Thaler, Ht" uniqKey="Thaler H">HT Thaler</name></author><author><name sortKey="Cella, D" uniqKey="Cella D">D Cella</name></author><author><name sortKey="Benda, J" uniqKey="Benda J">J Benda</name></author><author><name sortKey="Miller, Ds" uniqKey="Miller D">DS Miller</name></author><author><name sortKey="Olt, G" uniqKey="Olt G">G Olt</name></author><author><name sortKey="King, S" uniqKey="King S">S King</name></author><author><name sortKey="Boggess, Jf" uniqKey="Boggess J">JF Boggess</name></author><author><name sortKey="Rocereto, Tf" uniqKey="Rocereto T">TF Rocereto</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Napolitano, U" uniqKey="Napolitano U">U Napolitano</name></author><author><name sortKey="Imperato, F" uniqKey="Imperato F">F Imperato</name></author><author><name sortKey="Mossa, B" uniqKey="Mossa B">B Mossa</name></author><author><name sortKey="Framarino, Ml" uniqKey="Framarino M">ML Framarino</name></author><author><name sortKey="Marziani, R" uniqKey="Marziani R">R Marziani</name></author><author><name sortKey="Marzetti, L" uniqKey="Marzetti L">L Marzetti</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Okabayashi, H" uniqKey="Okabayashi H">H Okabayashi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Omura, Ga" uniqKey="Omura G">GA Omura</name></author><author><name sortKey="Blessing, Ja" uniqKey="Blessing J">JA Blessing</name></author><author><name sortKey="Vaccarello, L" uniqKey="Vaccarello L">L Vaccarello</name></author><author><name sortKey="Berman, Ml" uniqKey="Berman M">ML Berman</name></author><author><name sortKey="Clarke Pearson, Dl" uniqKey="Clarke Pearson D">DL Clarke-Pearson</name></author><author><name sortKey="Mutch, Dg" uniqKey="Mutch D">DG Mutch</name></author><author><name sortKey="Anderson, B" uniqKey="Anderson B">B Anderson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pecorelli, S" uniqKey="Pecorelli S">S Pecorelli</name></author><author><name sortKey="Zigliani, L" uniqKey="Zigliani L">L Zigliani</name></author><author><name sortKey="Odicino, F" uniqKey="Odicino F">F Odicino</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Peters, Wa" uniqKey="Peters W">WA Peters</name></author><author><name sortKey="Liu, Py" uniqKey="Liu P">PY Liu</name></author><author><name sortKey="Barrett, Rj" uniqKey="Barrett R">RJ Barrett</name></author><author><name sortKey="Stock, Rj" uniqKey="Stock R">RJ Stock</name></author><author><name sortKey="Monk, Bj" uniqKey="Monk B">BJ Monk</name></author><author><name sortKey="Berek, Js" uniqKey="Berek J">JS Berek</name></author><author><name sortKey="Souhami, L" uniqKey="Souhami L">L Souhami</name></author><author><name sortKey="Grigsby, P" uniqKey="Grigsby P">P Grigsby</name></author><author><name sortKey="Gordon, W" uniqKey="Gordon W">W Gordon</name></author><author><name sortKey="Alberts, Ds" uniqKey="Alberts D">DS Alberts</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Piver, Ms" uniqKey="Piver M">MS Piver</name></author><author><name sortKey="Rutledge, F" uniqKey="Rutledge F">F Rutledge</name></author><author><name sortKey="Smith, Jp" uniqKey="Smith J">JP Smith</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rydzewska, L" uniqKey="Rydzewska L">L Rydzewska</name></author><author><name sortKey="Tierney, J" uniqKey="Tierney J">J Tierney</name></author><author><name sortKey="Vale, Cl" uniqKey="Vale C">CL Vale</name></author><author><name sortKey="Symonds, Pr" uniqKey="Symonds P">PR Symonds</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sardi, Je" uniqKey="Sardi J">JE Sardi</name></author><author><name sortKey="Giaroli, A" uniqKey="Giaroli A">A Giaroli</name></author><author><name sortKey="Sananes, C" uniqKey="Sananes C">C Sananes</name></author><author><name sortKey="Ferreira, M" uniqKey="Ferreira M">M Ferreira</name></author><author><name sortKey="Soderini, A" uniqKey="Soderini A">A Soderini</name></author><author><name sortKey="Bermudez, A" uniqKey="Bermudez A">A Bermudez</name></author><author><name sortKey="Snaidas, L" uniqKey="Snaidas L">L Snaidas</name></author><author><name sortKey="Vighi, S" uniqKey="Vighi S">S Vighi</name></author><author><name sortKey="Gomez Rueda, N" uniqKey="Gomez Rueda N">N Gomez Rueda</name></author><author><name sortKey="Di Paola, G" uniqKey="Di Paola G">G di Paola</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schoenfeld, Da" uniqKey="Schoenfeld D">DA Schoenfeld</name></author><author><name sortKey="Richter, Jr" uniqKey="Richter J">JR Richter</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shimizu, Y" uniqKey="Shimizu Y">Y Shimizu</name></author><author><name sortKey="Akiyama, F" uniqKey="Akiyama F">F Akiyama</name></author><author><name sortKey="Umezawa, S" uniqKey="Umezawa S">S Umezawa</name></author><author><name sortKey="Ishiya, T" uniqKey="Ishiya T">T Ishiya</name></author><author><name sortKey="Utsugi, K" uniqKey="Utsugi K">K Utsugi</name></author><author><name sortKey="Hasumi, K" uniqKey="Hasumi K">K Hasumi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Spiegelhalter, Dj" uniqKey="Spiegelhalter D">DJ Spiegelhalter</name></author><author><name sortKey="Freedman, Ls" uniqKey="Freedman L">LS Freedman</name></author><author><name sortKey="Parmar, Mk" uniqKey="Parmar M">MK Parmar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Therasse, P" uniqKey="Therasse P">P Therasse</name></author><author><name sortKey="Arbuck, Sg" uniqKey="Arbuck S">SG Arbuck</name></author><author><name sortKey="Eisenhauer, Ea" uniqKey="Eisenhauer E">EA Eisenhauer</name></author><author><name sortKey="Wanders, J" uniqKey="Wanders J">J Wanders</name></author><author><name sortKey="Kaplan, Rs" uniqKey="Kaplan R">RS Kaplan</name></author><author><name sortKey="Rubinstein, L" uniqKey="Rubinstein L">L Rubinstein</name></author><author><name sortKey="Verweij, J" uniqKey="Verweij J">J Verweij</name></author><author><name sortKey="Van Glabbeke, M" uniqKey="Van Glabbeke M">M Van Glabbeke</name></author><author><name sortKey="Van Oosterom, At" uniqKey="Van Oosterom A">AT van Oosterom</name></author><author><name sortKey="Christian, Mc" uniqKey="Christian M">MC Christian</name></author><author><name sortKey="Gwyther, Sg" uniqKey="Gwyther S">SG Gwyther</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Trotti, A" uniqKey="Trotti A">A Trotti</name></author><author><name sortKey="Byhardt, R" uniqKey="Byhardt R">R Byhardt</name></author><author><name sortKey="Stetz, J" uniqKey="Stetz J">J Stetz</name></author><author><name sortKey="Gwede, C" uniqKey="Gwede C">C Gwede</name></author><author><name sortKey="Corn, B" uniqKey="Corn B">B Corn</name></author><author><name sortKey="Fu, K" uniqKey="Fu K">K Fu</name></author><author><name sortKey="Gunderson, L" uniqKey="Gunderson L">L Gunderson</name></author><author><name sortKey="Mccormick, B" uniqKey="Mccormick B">B McCormick</name></author><author><name sortKey="Morrisintegral, M" uniqKey="Morrisintegral M">M Morrisintegral</name></author><author><name sortKey="Rich, T" uniqKey="Rich T">T Rich</name></author><author><name sortKey="Shipley, W" uniqKey="Shipley W">W Shipley</name></author><author><name sortKey="Curran, W" uniqKey="Curran W">W Curran</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Japon</li></country></list><tree><country name="Japon"><noRegion><name sortKey="Katsumata, N" sort="Katsumata, N" uniqKey="Katsumata N" first="N" last="Katsumata">N. Katsumata</name></noRegion><name sortKey="Hiura, M" sort="Hiura, M" uniqKey="Hiura M" first="M" last="Hiura">M. Hiura</name><name sortKey="Kamura, T" sort="Kamura, T" uniqKey="Kamura T" first="T" last="Kamura">T. Kamura</name><name sortKey="Kasamatsu, T" sort="Kasamatsu, T" uniqKey="Kasamatsu T" first="T" last="Kasamatsu">T. Kasamatsu</name><name sortKey="Kobayashi, H" sort="Kobayashi, H" uniqKey="Kobayashi H" first="H" last="Kobayashi">H. Kobayashi</name><name sortKey="Kodama, S" sort="Kodama, S" uniqKey="Kodama S" first="S" last="Kodama">S. Kodama</name><name sortKey="Kuzuya, K" sort="Kuzuya, K" uniqKey="Kuzuya K" first="K" last="Kuzuya">K. Kuzuya</name><name sortKey="Mizunoe, T" sort="Mizunoe, T" uniqKey="Mizunoe T" first="T" last="Mizunoe">T. Mizunoe</name><name sortKey="Nakanishi, T" sort="Nakanishi, T" uniqKey="Nakanishi T" first="T" last="Nakanishi">T. Nakanishi</name><name sortKey="Saito, T" sort="Saito, T" uniqKey="Saito T" first="T" last="Saito">T. Saito</name><name sortKey="Shibata, T" sort="Shibata, T" uniqKey="Shibata T" first="T" last="Shibata">T. Shibata</name><name sortKey="Yaegashi, N" sort="Yaegashi, N" uniqKey="Yaegashi N" first="N" last="Yaegashi">N. Yaegashi</name><name sortKey="Yasugi, T" sort="Yasugi, T" uniqKey="Yasugi T" first="T" last="Yasugi">T. Yasugi</name><name sortKey="Yokota, H" sort="Yokota, H" uniqKey="Yokota H" first="H" last="Yokota">H. Yokota</name><name sortKey="Yoshikawa, H" sort="Yoshikawa, H" uniqKey="Yoshikawa H" first="H" last="Yoshikawa">H. Yoshikawa</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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